Savannah Guthrie’s sister is believed to be the last person who saw their now-missing mom just hours before she was allegedly snatched from her bed, according to a report.

Annie Guthrie reportedly told Arizona cops she didn’t see “any red flags” while enjoying dinner with Nancy, 84, on Jan. 31 before the matriarch returned to her million-dollar Catalina Foothills home, according to US Weekly.

Nancy’s disappearance is being treated as a crime and Chris Nanos, the Pima County Sheriff, believes she was abducted and taken against her will. Blood was found in the home and there were signs of forced entry, law enforcement sources told The Los Angeles Times.

She was reported missing around noon on Sunday after failing to show up for church but Nanos said the “start point” in the case is earlier.

“The family took her home from dinner at about 9:30 to 9:45 on Saturday, January 31. So we would back that up to even say 9 or 8:30 p.m. to start looking,” he told US Weekly.

Nancy cannot walk 50 yards on her own and is dependent on life-saving meds. Cops previously warned that 24 hours without the medication could be fatal for her.

Her cell phone, car, and wallet were left behind at the home and DNA was recovered at the scene – which has been sent to a Phoenix lab, as reported by KPNX.

Investigators took DNA samples but it could take several days for the results to come back, according to Nanos.

Nancy has been missing for almost 48 hours and Nanos warned timing is “very critical” to law enforcement.

“The longer this goes on the more danger she faces,” he said.

Drones, search dogs, volunteers and Border Patrol officials have all been involved in the search, as well as homicide officials. It’s not common for homicide officials to be involved in a missing persons case.

“Today” star Savannah didn’t appear on Monday’s show before thanking her social media followers for their prayers.

“We believe in prayer. We believe in voices raised in unison, in love, in hope. We believe in goodness,” she wrote in a Monday night Instagram post.

“We believe in humanity. Above all, we believe in Him,” she wrote along with a photo that reads, ‘Please pray.’”

“Thank you for lifting your prayers with ours for our beloved mom, our dearest Nancy, a woman of deep conviction, a good and faithful servant,” the post continued.

“Raise your prayers with us and believe with us that she will be lifted by them in this very moment.”

Nancy’s neighbors have been urged to review any surveillance video they may have in a bid to help cops.