John Stamos isn’t one to mince words, especially when it comes to his rock-solid marriage or the enduring bromance-turned-sisterhood with his Full House co-star Lori Loughlin. In a candid episode of the Good Guys podcast dropped on October 20, the 62-year-old actor shut down fan speculation about rekindling old flames with the newly single Loughlin—now 61 and freshly separated from husband Mossimo Giannulli after 27 years—with a profanity-laced zinger that left hosts Josh Peck and Ben Soffer chuckling. “No f***ing way,” Stamos declared when asked point-blank if he’d ever leave his wife of seven years, Caitlin McHugh, for the woman who played his on-screen spouse, Aunt Becky. “I’m not Mormon.” The quip, a nod to polygamy stereotypes, underscored his unwavering loyalty, but the conversation quickly veered into nostalgic territory, unearthing decades of what-ifs, near-misses, and the ugly underbelly of Loughlin’s recent personal upheavals.

The podcast, hosted by Peck (Drake & Josh) and Soffer, served as a fan Q&A bonanza, with listeners bombarding the show ahead of time about the Full House duo’s chemistry. “The biggest question was, ‘Come on. Aunt Becky. Bring her in. Would you leave your wife for her?’” Soffer read aloud, prompting Stamos to laugh it off before diving deeper. Their bond dates back to the late 1980s, predating the show’s 1987 premiere. Stamos and Loughlin, both rising stars, even squeezed in a Disneyland date as young adults, but it fizzled before sparking. “There was a very small window of the two of us being single at the same time,” Stamos reflected in his 2023 memoir, If You Would Have Told Me, a sentiment he echoed on the pod. To illustrate, he borrowed a Grease analogy: Loughlin as the innocent Sandy before her leather-clad transformation, while his ex-wife Rebecca Romijn embodied the edgier post-“Tell Me About It, Stud” version. “I was more into the rebellious,” he admitted. “Lori was so sweet, and I loved working with her, but she was too nice for me.”

That “sweetness” is exactly what Stamos credits for their platonic longevity—a 40-year friendship that’s weathered Hollywood’s highs and lows. They reunited in 2024 for a nostalgic Full House vow renewal event, recreating their characters’ 1991 wedding amid laughs and tears. Loughlin lives in Stamos’ neighborhood, and he’s been a steady presence through her storms, including the 2019 Varsity Blues college admissions scandal that landed her two months in prison. On the podcast, Stamos didn’t hold back, pinning the blame squarely on Giannulli, whom he branded a “narcissist.” “All the negativity or hardships that you’ve been through in your life is connected to this guy,” he told Loughlin during a heart-to-heart, per his recounting. The couple’s separation, announced earlier this month with a terse “living apart” statement and no legal filings yet, has left her “devastated,” Stamos said. “Whatever he did to her, it busted her up to the core. She put up with a lot over the years.”

When pressed on cheating rumors swirling around Giannulli—fueled by tabloid whispers and Loughlin’s inner circle—Stamos played coy: “I’m taking the Fifth.” But he made his stance crystal clear: “I will never talk to him again.” It’s a protective streak that’s defined their dynamic since the scandal erupted. In 2022, on Dax Shepard’s Armchair Expert, Stamos called Loughlin “a saint” and insisted she “wasn’t really the architect of any of it,” defending her as a “good person, a good mother, a good wife.” Post-prison, she quipped to him about her time inside: “I met a lot of nice ladies. We have a book club.” The levity masked deeper pain, and Stamos has been vocal about her resilience. “For a girl who has lived her life really well… to be thrown into this separation and blowing up her family this way. I just hate to see her go through this.”

Stamos’ own romantic history adds layers to the tale. Married to Romijn from 1998 to 2005, he navigated a messy split amid rumors of infidelity. His 2018 union with McHugh, 38 years his junior, has been a stabilizing force—complete with a son, Billy, now 6, and a Beverly Hills lifestyle blending family hikes with red-carpet glamour. McHugh’s “been good about it,” Stamos noted of Loughlin’s visits, emphasizing boundaries. “She’s just a friend,” he clarified, shutting down any notion of an open marriage or Full House redux romance. Fans, however, eat up the fantasy—their on-screen sparks as Uncle Jesse and Aunt Becky fueled endless “shipper” debates, amplified by the show’s wholesome reboot Fuller House.

The podcast timing couldn’t be more poignant. Loughlin and Giannulli’s split—after decades of building the Mossimo fashion empire—comes amid ongoing scandal echoes. She served time in FCI Dublin, a low-security California facility, emerging in December 2020 to rebuild quietly: low-key roles in Hallmark movies, charity work with the Boys & Girls Clubs, and co-parenting daughters Olivia, 25, and Isabella, 23. Giannulli, five months in prison, has kept a lower profile, but Stamos’ barbs suggest unresolved grudges. TMZ reported Giannulli had “no comment” on the allegations, but insiders hint at a drawn-out divorce battle over assets exceeding $100 million.

Stamos, fresh off Broadway’s How to Succeed in Business Without Really Trying and a Scream cameo, used the platform to humanize Loughlin beyond the headlines. “She’s an angel, and she always made things better. She cleaned everything up,” he said of her crisis management. It’s a sentiment echoed by Full House alums like Candace Cameron Bure and Jodie Sweetin, who’ve rallied around her. Yet, Stamos knows the internet’s relentless—memes of Jesse and Becky’s wedding flooded social media post-episode, alongside thirsty fan art and “what if” threads on Reddit.

Experts in celebrity psychology, like Dr. Ramani Durvasula, see the exchange as a masterclass in boundaries. “Stamos is modeling healthy friendship in Hollywood’s pressure cooker,” she told the Desk. “Affirming affection without crossing lines—especially with a vulnerable friend—shows emotional intelligence.” For Loughlin, it’s validation amid scrutiny; for Stamos, a reminder of growth from his wilder youth.

As autumn leaves fall in L.A., Stamos and McHugh prep for Billy’s Halloween bash—likely sans drama. Loughlin? She’s focusing on healing, per sources, with Stamos in her corner. Their story? A testament to platonic power in a tabloid world. No leather jackets required.

The Entertainment Desk reached out to Stamos’ reps, McHugh, and Loughlin’s team; all declined comment. Giannulli’s camp reiterated: “No further statement.”