A Nebraska woman has captured widespread attention after celebrating her 20th birthday on November 4, 2025, despite being born with a rare condition that left her with virtually no brain tissue—a development doctors once deemed unlikely beyond early childhood. Alex Simpson of Omaha was diagnosed shortly after birth with hydranencephaly, a severe congenital disorder where the cerebral hemispheres are absent and replaced by sacs filled with cerebrospinal fluid, according to medical experts and family accounts shared with local media.

Hydranencephaly occurs in approximately one in 5,000 to one in 10,000 pregnancies, and it is typically fatal within the first year of life, the Cleveland Clinic reports. In Alex’s case, her father, Shawn Simpson, explained to outlets that she retains only a tiny portion of brain tissue—”about half the size of my pinky finger” in the cerebellum—while the rest is absent.

Parents Lorena and Shawn Simpson recalled the heartbreaking moment in 2005 when doctors delivered the news on New Year’s Day, shortly after Alex’s birth. “Doctor Davey came in with his nurses and said, ‘You guys need iterated to sit down. This is pretty serious,’” they told KETV, the ABC affiliate in Omaha that has followed Alex’s story for years. At the time, physicians estimated she would not survive past age 4, prompting the family to lean heavily on faith and community support.

Yet Alex has continued to thrive in ways that have astonished medical professionals and inspired those around her. The family revisited her 10th birthday milestone with KETV a decade ago, and returned for the 20th, highlighting her calmer demeanor and improved health over the years. While Alex lacks the brain regions responsible for sight and hearing, her loved ones describe a vibrant personality that shines through. “When I went up there and talked to her a little bit ago, she was looking for me,” Shawn shared, noting how she responds to voices and presence.

Her younger brother, SJ, echoed this, saying Alex seems to sense family emotions, such as radiating calm during tough times. The Simpsons attribute her longevity to unwavering love and spiritual strength. “Twenty years ago, we were scared but faith, I think, is really what kept us alive,” Shawn reflected. Lorena added that daily care routines filled with affection have made all the difference.

Coverage of Alex’s birthday exploded across national outlets, with People magazine dubbing her a “fighter” in a November 9 feature that detailed the family’s journey. Stations like Local 12 and News 4 San Antonio syndicated the KETV report, emphasizing how Alex’s story serves as a beacon of hope. “Miracles still happen,” her parents told reporters, crediting community encouragement and medical advancements in supportive care.

Hydranencephaly differs from related conditions like anencephaly, where the brain and skull fail to develop fully, often resulting in shorter lifespans. Cases of long-term survival are exceptionally rare, making Alex one of the oldest known individuals with the disorder. Medical literature notes that affected children may rely on brainstem functions for basic reflexes, but higher cognition is limited.

The Simpsons have shared updates over the years, including Alex’s ability to enjoy family gatherings, music, and sensory experiences. Photos from the 20th birthday show a joyful celebration with balloons, cake, and loved ones surrounding her wheelchair. Siblings and extended family describe her as the heart of their home, bringing unity and perspective.

Experts consulted in similar cases stress the role of palliative care, family dedication, and occasional medical interventions like shunts to manage fluid buildup. While no cure exists, advancements in neurology have improved quality of life for rare survivors.

Social media reactions poured in following the stories, with users calling Alex an “inspiration” and praising the Simpsons’ resilience. Hashtags like #AlexStrong trended locally, and fundraisers for adaptive equipment gained traction.

As Alex enters her third decade, her family looks forward with optimism. “Love” is the word they repeat when asked how she’s defied expectations. Shawn summed it up: “She’s a fighter.”

This milestone underscores broader themes in rare disease communities—hope, advocacy, and the power of support networks. Organizations like the Hydranencephaly Foundation highlight stories like Alex’s to raise awareness and funds for research.

In a world often focused on challenges, Alex Simpson’s 20 years stand as a testament to human spirit. Her parents hope her journey encourages others facing similar diagnoses to embrace each day.

The Omaha community rallied for the birthday, with local businesses donating decorations and treats. KETV’s ongoing coverage has turned Alex into a regional symbol of perseverance.

Looking ahead, the family plans quieter celebrations while continuing routine care. “She’s calmer and healthier,” Lorena noted, grateful for every moment.

Alex’s case joins a handful of documented long-term hydranencephaly survivors, prompting ongoing medical interest. Neurologists point to brain plasticity and family environment as key factors in outcomes.

As reports spread via AOL, MySuncoast, and 1011 NOW, viewers shared personal connections, from faith-based encouragement to calls for more pediatric research funding.

Twenty years after a prognosis that shattered expectations, Alex Simpson continues to touch lives—proving that sometimes, the greatest strengths come from the most unexpected places.