Blood was found in the home of “Today” co-host Savannah Guthrie’s missing 84-year-old mom, — with the local sheriff confirming that authorities fear “a possible kidnapping or abduction.”

The blood was found alongside signs of forced entry and a struggle in the house in Catalina Hills, Arizona, law enforcement sources told The Post. It was not immediately confirmed whose blood it was.

Nancy Guthrie, whom Savannah calls her “best friend,” was reported missing Sunday, hours after returning from dinner the night before.

“At this point, investigators believe she was taken from the home against her will, possibly [in the] middle of the night,” Pima County Sheriff’s Department spokesperson Kevin Adger confirmed to the LA paper.

“Detectives are looking into a possible kidnapping or abduction.”

Police also announced a $2,500 reward while asking for images, videos, or details that lead to the alleged abductor’s arrest.

Pima County Sheriff Chris Nanos appealed directly to anyone involved.

“Just call us. Let her go. Just call us. The family will tell you, there’s no questions asked here,” he told NBC News. “We don’t need another bad, tragic ending.”

DNA evidence found at the home is being combed over, according to KVOA.

Nancy Guthrie left her car and cellphone at the scene, according to investigators who hope data from the phone might help point to when she was snatched, according to ABC News.

Nancy was reported missing at noon Sunday after failing to show up for a church service.

She cannot walk more than 50 yards on her own and is reliant on life-saving medication, according to cops.

The hunt is a race against time because the missing woman needs medication, lack of which for 24 hours could prove fatal.

“We’re doing all we can to try to locate her,” Nanos said. “Every tool we have, we will use.”